abstract：:Pituitary adenomas are common neoplasms requiring medical and/or surgical treatment when associated with hormonal hypersecretion. Treatment of non-functioning pituitary adenomas is necessary when symptoms of mass effect or hormonal deficits occur. However, therapeutic options, including surgical resection and/or radio...

journal_title：Journal of endocrinological investigation

authors： Ballian N,Chrisoulidou A,Nomikos P,Samara C,Kontogeorgos G,Kaltsas GA

更新日期：2007-09-01 00:00:00

abstract：:No long-term data are available on the efficacy of glargine insulin in comparison with continuous sc insulin infusion (CSII) in children and adolescents affected by Type 1 diabetes (T1D). Our aim was to compare the 2-yr efficacy of the 2 insulin approaches, in order to know how to best supply basal insulin in these pa...

journal_title：Journal of endocrinological investigation

authors： Schiaffini R,Patera PI,Bizzarri C,Ciampalini P,Cappa M

更新日期：2007-07-01 00:00:00

abstract：:Finding that estrogen plays an important role in bone homeostasis in men prompted research on relationship of polymorphism at the CYP19 gene and the bone mass. Therefore, influence of 3-bp deletion/insertion polymorphism of CYP19 (TTTA)7 allele on the peak bone mass attainment in males was studied. Fifty-eight unrelat...

journal_title：Journal of endocrinological investigation

authors： Kastelan D,Grubic Z,Kraljevic I,Duric K,Kardum I,Dusek T,Stingl K,Giljevic Z,Kerhin-Brkljacic V,Suchanek E,Korsic M

更新日期：2007-06-01 00:00:00

abstract：:Cushing's Syndrome (CS) may sometimes lead to dilated cardiomyopathy, even though this condition can be partially or completely reversed after treatment. In this article we report the case of a 28-yr-old woman with CS secondary to adrenal adenoma who exhibited congestive heart failure as an initial symptom. Two weeks ...

journal_title：Journal of endocrinological investigation

authors： Petramala L,Battisti P,Lauri G,Palleschi L,Cotesta D,Iorio M,De Toma G,Sciomer S,Letizia C

更新日期：2007-06-01 00:00:00

abstract：:Hyperthyroidism is rare in early childhood and most commonly caused by Graves' disease. We report 14 children (4 boys, 10 girls) aged 3.4-7.5 yr. At diagnosis, all patients had weight loss, hyperkinetic activity, tachycardia, difficulty sleeping, and poor concentration and 11 presented with proptosis. Four patients de...

journal_title：Journal of endocrinological investigation

authors： Bossowski AT,Reddy V,Perry LA,Johnston LB,Banerjee K,Blair JC,Savage MO

更新日期：2007-05-01 00:00:00

abstract：:Recent evidence suggests that patients with traumatic brain injury (TBI) are at substantial risk of hypopituitarism. The pathomechanisms, however, are not completely understood yet. Little is known about the association of morphological changes in the sella region with pituitary function in TBI. In this study, we asse...

journal_title：Journal of endocrinological investigation

authors： Schneider HJ,Sämann PG,Schneider M,Croce CG,Corneli G,Sievers C,Ghigo E,Stalla GK,Aimaretti G

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Visfatin [pre-B cell colony- enhancing factor (PBEF)] is a cytokine highly expressed in visceral fat that exhibits insulin-mimetic properties. However, its role in insulin-resistant states, such as in metabolic syndrome (MetS), remains largely unknown. OBJECTIVE:To investigate the possible differences of pl...

journal_title：Journal of endocrinological investigation

authors： Filippatos TD,Derdemezis CS,Kiortsis DN,Tselepis AD,Elisaf MS

更新日期：2007-04-01 00:00:00

abstract：:Thyroid diseases may lead to endothelial dysfunction; however, the mechanism underlying the endothelial dysfunction in thyroid disease is not clear yet. Asymmetric dimethylarginine (ADMA), a novel inhibitor of endothelial nitric oxide synthase (eNOS), blocks nitric oxide (NO) synthesis from L-arginine. Symmetric dimet...

journal_title：Journal of endocrinological investigation

authors： Arikan E,Karadag CH,Guldiken S

更新日期：2007-03-01 00:00:00

abstract：:We report a case of pulmonary multinodular mucormycosis in a Type 1 diabetic patient with diabetic ketoacidosis. He had a history of 20-pack-year tobacco use. The initial chest roentgenogram and thorax tomography (after the treatment of diabetic ketoacidosis) revealed multiple nodular lesions with cavitation in the up...

journal_title：Journal of endocrinological investigation

authors： Kebapci N,Efe B,Alataş F,Açikalin M,Kiraz N

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Serum DHEAS has been found to be elevated in some women with polycystic ovary syndrome (PCOS). We wished to determine whether this prevalence is different in women with androgen excess who have different phenotypes and to correlate these findings with various cardiovascular and metabolic parameters. METHODS...

journal_title：Journal of endocrinological investigation

authors： Carmina E,Lobo RA

更新日期：2007-02-01 00:00:00

abstract：:Osteoporosis is a multifactorial chronic disease that may become even more prevalent and more of a public health problem in the decades to come. Recent research has indicated that a number of macro- and micronutrients are involved in the development of bone health. In the past decade it became evident that vitamin K p...

journal_title：Journal of endocrinological investigation

authors： Francucci CM,Rilli S,Fiscaletti P,Boscaro M

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the hypothesis that interleukin-1beta (IL-1beta) might be involved in the increase of the circulating levels of placental-derived CRH leading to the initiation of pre-term labor. SUBJECTS AND METHODS:Forty-eight primigravidae with a singleton viable pregnancy between ...

journal_title：Journal of endocrinological investigation

authors： Vitoratos N,Mastorakos G,Kountouris A,Papadias K,Creatsas G

更新日期：2007-01-01 00:00:00

abstract：:The physiological pulsatile secretion of GH in humans might be important for the metabolic effects of GH. In the treatment of GH-deficient (GHD) patients, the most common regimen is a single sc injection at bedtime. It has not been completely established if this is the optimal mode of GH administration during long-ter...

journal_title：Journal of endocrinological investigation

authors： Höybye C,Rudling M

更新日期：2006-12-01 00:00:00

abstract：:Obesity is associated with a number of serious diseases and with a degree of motor disability, but the extent of the risk and functional derangement within the obese population is not yet completely defined. The study aims to evaluate the combined effect of degree of adiposity, body fat distribution and age on selecte...

journal_title：Journal of endocrinological investigation

authors： Lafortuna CL,Agosti F,Proietti M,Adorni F,Sartorio A

更新日期：2006-11-01 00:00:00

abstract：:To evaluate the influence of chronological age and pubertal development on the hypothalamus-pituitary-adrenal (HPA) axis response to stress, we studied the possible correlations between male pubertal characteristics and salivary cortisol (C), DHEAS and the DHEAS/C ratio before (pre-stress) and after acute exercise-str...

journal_title：Journal of endocrinological investigation

authors： Di Luigi L,Guidetti L,Baldari C,Gallotta MC,Sgrò P,Perroni F,Romanelli F,Lenzi A

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:The determination of (a) iodine deficiency, and (b) the relation between the iodized salt consumption in the Isparta province of Turkey. METHODS:Five hundred students between 6-11 yr of age were evaluated. With a questionnaire, the subjects were asked whether they were using iodine-containing salt or not. Af...

journal_title：Journal of endocrinological investigation

authors： Cetin H,Kisioglu AN,Gursoy A,Bilaloglu E,Ayata A

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:The relative contribution of fasting and post-prandial glucose to glycated hemoglobin (HbA1c) is controversial. In the present study, we assessed the relationship with HbA1c of fasting and post-prandial glucose measured in a more naturalistic setting, through home glucose self-monitoring or with a continuous ...

journal_title：Journal of endocrinological investigation

authors： Monami M,Lamanna C,Lambertucci L,Longo R,Cocca C,Addante F,Lotti E,Masotti G,Marchionni N,Mannucci E

更新日期：2006-07-01 00:00:00

abstract：:Multiple endocrine neoplasia type 1 (MEN1) is characterized by parathyroid, enteropancreatic endocrine and pituitary adenomas as well as germline mutation of the MEN1 gene. We describe 2 families with MEN1 with novel mutations in the MEN1 gene. One family was of Turkish origin, and the index patient had primary hyperp...

journal_title：Journal of endocrinological investigation

authors： Ozturk M,Chiu CY,Akdeniz N,Jenq SF,Chang SC,Hsa CY,Jap TS

更新日期：2006-06-01 00:00:00

abstract：:Androgen insensitivity is a disorder characterized by an abnormal male sexual development, in which the androgen action is impaired due to structural defects in the androgen receptor gene. We report a case of a 46,XY subject with female phenotype (normal breast and external genitalia) lacking sexual hair, affected wit...

journal_title：Journal of endocrinological investigation

authors： Moretti C,Odorisio T,Geremia R,Grimaldi P

更新日期：2006-05-01 00:00:00

abstract：:The present study investigated whether trophoblast, decidua and fetal membranes express nerve growth factor (NGF) mRNA and peptide. Tissue specimens were collected in the first and third trimester of pregnancy from women undergoing voluntary pregnancy interruption (no.= 6; from 8 to 12 gestational weeks) and from wome...

journal_title：Journal of endocrinological investigation

authors： Toti P,Ciarmela P,Florio P,Volpi N,Occhini R,Petraglia F

更新日期：2006-04-01 00:00:00

abstract：:Numerous clinical and experimental reports suggest that a high von Willebrand factor (vWf) level reflects endothelial damage or endothelial dysfunction. The present study was designed to evaluate vWf in subclinical hyperthyroidic subjects compared with euthyroidic subjects. We selected 20 subclinical hyperthyroidic su...

journal_title：Journal of endocrinological investigation

authors： Coban E,Aydemir M,Yazicioglu G,Ozdogan M

更新日期：2006-03-01 00:00:00

abstract：:The autosomal dominant familial neurohypophyseal diabetes insipidus (adFNDI) is caused by diverse mutations in one allele of the gene that encodes the arginine vasopressin (AVP) precursor protein, AVP-neurophysin II (AVP-NP II). Most of the mutations identified so far are located in either the signal peptide or NP II ...

journal_title：Journal of endocrinological investigation

authors： Kobayashi H,Fujisawa I,Ikeda K,Son C,Iwakura T,Yoshimoto A,Kasahara M,Ishihara T,Ogawa Y

更新日期：2006-03-01 00:00:00

abstract：:D-aspartic acid (D-Asp), aromatase enzyme activity and the putative D-Asp involvement on aromatase induction have been studied in the testis of mature boars. The peroxidase-antiperoxidase and the indirect immunofluorescence methods, applied to cryostat and paraffin sections, were used to evaluate D-Asp and aromatase d...

journal_title：Journal of endocrinological investigation

authors： Lamanna C,Assisi L,Botte V,Di Fiore MM

更新日期：2006-02-01 00:00:00

abstract：:Although adjustments to nutritional lifestyle and increased physical activity remain the milestones of weight loss therapy, it is evident from the exponential increase of the number of obese subjects in Western countries that these two approaches alone are no longer able to limit this progression. This alarming phenom...

journal_title：Journal of endocrinological investigation

authors： Pagotto U,Pasquali R

更新日期：2006-01-01 00:00:00

abstract：:Silver-Russell syndrome (SRS) is both clinically and genetically a heterogeneous congenital disorder. Patients are characterised by severe intrauterine and post-natal growth retardation, dysmorphic facial features and, asymmetry. Various chromosome abnormalities have been associated with the disease, involving most of...

journal_title：Journal of endocrinological investigation

authors： Rossignol S

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The aim of the study was to evaluate diurnal blood pressure (BP) profiles in patients with primary aldosteronism and to compare them to those in subjects with essential hypertension. The effects of specific therapy on the circadian BP profiles have been studied. MATERIALS AND METHODS:Sixty-four patients wit...

journal_title：Journal of endocrinological investigation

authors： Zacharieva S,Orbetzova M,Elenkova A,Stoynev A,Yaneva M,Schigarminova R,Kalinov K,Nachev E

更新日期：2006-01-01 00:00:00

abstract：:The aim of acromegaly treatment is to control the disease by suppressing GH hyperactivity and reducing the size or impeding the growth of the pituitary GH secreting mass. Over recent years, many studies have emphasized the role of SS analogs in the treatment of acromegaly. In fact, SS analogs have been demonstrated to...

journal_title：Journal of endocrinological investigation

authors： Gola M,Bonadonna S,Mazziotti G,Amato G,Giustina A

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:During application of orthodontic force on the tooth, various molecular parameters associated with tissue remodeling are changed. IGF-I is a regulatory protein produced during periodontal regeneration. IGF binding proteins-3 (IGFBP-3), a specific IGF-I binding protein, is the major regulatory factor of IGF-I...

journal_title：Journal of endocrinological investigation

authors： Toia M,Galazzo R,Maioli C,Granata R,Scarlatti F

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:Neuroendocrine dysfunction in polycystic ovary syndrome (PCOS) was addressed by studying the steroid hormone changes in women with PCOS with either high or normal LH levels leading to inferences regarding the primacy of elevated LH in the pathophysiology of PCOS. METHODS:A cross-sectional study was designed ...

journal_title：Journal of endocrinological investigation

authors： Doi SA,Al-Zaid M,Towers PA,Scott CJ,Al-Shoumer KA

更新日期：2005-11-01 00:00:00

abstract：:The 1865 volume of the "II Morgagni", one of the most important Italian medical journals of the 19th century, presented two important articles, milestones for further scientific studies in the field of sexual differentiation. One was the original description of the "ramified cells" of testicular tubules by E. Sertoli,...

journal_title：Journal of endocrinological investigation

authors： Virdis R

更新日期：2005-11-01 00:00:00

abstract：:The genetic factors determining bone mineral density (BMD) are not well characterized. Many studies have investigated the relationship between the fokI polymorphism of vitamin D receptor (VDR) gene in diverse populations and gender, resulting in conflicting outcomes. Because peak bone mass in men is closely related to...

journal_title：Journal of endocrinological investigation

authors： Bolu SE,Orkunoglu Suer FE,Deniz F,Uckaya G,Imirzalioglu N,Kutlu M

更新日期：2005-10-01 00:00:00

abstract：:Over the last decade, there has been an alarming increase of Type 2 diabetes mellitus (T2DM) in youths, concomitant with the rise of obesity in this age group. T2DM is a progressive disease with a gradual increase in insulin resistance associated later with a decline in insulin secretion with fasting hyperglycemia. Pr...

journal_title：Journal of endocrinological investigation

authors： Marcovecchio M,Mohn A,Chiarelli F

更新日期：2005-10-01 00:00:00

abstract：:We hereby present a rare variant of multiple endocrine neoplasia type 2A (MEN2A) associated with a rare skin disease primary cutaneous lichen amyloidosis and discrete malignant pheochromocytoma in both adrenal glands and pancreatic tail, and interestingly accompanied ganglioneuroma located in retroperitoneum in a 34-y...

journal_title：Journal of endocrinological investigation

authors： Gullu S,Gursoy A,Erdogan MF,Dizbaysak S,Erdogan G,Kamel N

更新日期：2005-09-01 00:00:00

abstract：:Entering puberty is one of the most important milestones in life. Studies from around the world have shown that age of pubertal changes onset can vary with race and ethnicity, environmental conditions, geographical location and nutrition. In the last century, the onset of puberty progressively shifted back towards you...

journal_title：Journal of endocrinological investigation

authors： Castellino N,Bellone S,Rapa A,Vercellotti A,Binotti M,Petri A,Bona G

更新日期：2005-07-01 00:00:00

abstract：:Male to female sex reversal results from failure of testis development. Mutations in the SRY gene or in other genes involved in the sexual differentiation pathway are considered to cause XY gonadal dysgenesis. The majority of the mutations in the SRY described so far are located within the SRY coding region, mainly in...

journal_title：Journal of endocrinological investigation

authors： Assumpção JG,Ferraz LF,Benedetti CE,Maciel-Guerra AT,Guerra G Jr,Marques-de-Faria AP,Baptista MT,de Mello MP

更新日期：2005-07-01 00:00:00

abstract：:It has recently been suggested that the classical routine of glucocorticoid administration before and after transsphenoidal surgery (TSS) in Cushing's disease (CD) patients may not be necessary, since it is likely that peritumoral normal corticotrophs are not completely suppressed during this period. We compared the d...

journal_title：Journal of endocrinological investigation

authors： Pimentel-Filho FR,Silva ME,Nogueira KC,Berger K,Cukiert A,Liberman B

更新日期：2005-06-01 00:00:00

abstract：:Pheochromocytoma (PHEO) occasionally associates with pathological lesions of the adrenal cortex. In most of them, ectopic adrenocorticotropic hormone (ACTH) produced by PHEO resulted in bilateral adrenocortical hyperplasia. The coexistence of PHEO and pre-clinical Cushing's syndrome (PCS) of the same adrenal gland has...

journal_title：Journal of endocrinological investigation

authors： Erem C,Hacihasanoglu A,Ersöz HO,Reis AK,Calik A,Ukinç K,Koçak M

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:We previously demonstrated that patients suffering from moderate hypothyroidism were at increased risk of thrombosis contrasting with the bleeding tendency of those presenting severe hypothyroidism. The latter state is associated with hemostatic anomalies including von Willebrand type 1 disease and increased ...

journal_title：Journal of endocrinological investigation

authors： Chadarevian R,Jublanc C,Bruckert E,Giral P,Ankri A,Leenhardt L,Chapman J,Turpin G

更新日期：2005-05-01 00:00:00

abstract：:Pituitary metastases account for about 1% of operated pituitary lesions. Most derive from primaries in the breast or lung. Pituitary metastases from hepatocellular carcinoma (HCC) have rarely been reported. We describe a patient in whom headache and left external ophthalmoplegia were the only presenting signs of a cli...

journal_title：Journal of endocrinological investigation

authors： Hirsch D,Benbassat CA,Drozd T,Okon E,Blum I

更新日期：2005-05-01 00:00:00

abstract：:The aim of our study was to investigate the effects of estradiol (E2) and/or progesterone (P4) bilateral ovariectomized rats on gene expressions of adenylyl cyclases (AC2, AC4, AC6, AC9). Non-pregnant (NP) Wister rats (between post-natal 10 and 12 weeks) and normal pregnant rats (between postnatal 10 and 14 weeks) wer...

journal_title：Journal of endocrinological investigation

authors： Asano K,Okawa T,Matsuoka I,Suzuki Y,Sato A

更新日期：2005-04-01 00:00:00